Equations : Total body iron deficit (mg) = body weight (kg) x (target Hb - actual Hb in g/dL) x 2.4 + iron depot (mg)** [1, 2] Iron depot: 15 mg/kg for body weight less than 35 kg 500 mg for those with a body weight greater than or equal to 35 kg Ideal Body Weight (kg) =45.5 +2.3 * (height inches - 60 inches) [3] By clicking send, you acknowledge that you have permission to email the recipient with this information. Estimates the iron deficit in preparation for iron replacement based on patient weight and haemoglobin. calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment, Hemodialysis-dependent chronic kidney disease (HDD-CKD)*, Non-dialysis-dependent chronic kidney disease (NDD-CKD), Peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD), At a dose of 0.5 mg/kg, not to exceed 100 mg per dose, Given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at concentrations of 1 to 2 mg/mL and administered over 5 to 60 minutes, An increase in Hb concentration or a decrease in ESA dose is desired and. Assessing new treatment options. UpToDate. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. Pain, swelling, or redness at the injection site may occur. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hemoglobin conc. Applies only to oral form of both agents. an automated flowchart approach. iron sucrose increases levels of calcium citrate by enhancing GI absorption. If these effects continue or worsen, tell your doctor.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Case G. Maintaining iron balance with total-dose infusion of intravenous iron dextran. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Applies only to oral form of both agents. 4. You are encouraged to report Adverse Drug Events to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. Venofer Injection Dosage Guide - Drugs.com By taking into account the case of a patient weighing 78 kg (172 lbs) and having a hemoglobin level of 11 g/dL (110 g/L or 6.83 mmol/L). Share cases and questions with Physicians on Medscape consult. Parenteral iron dextran therapy. The plasma ferritin level as a reliable index of body iron stores following intravenous iron dextran. Drug class: Iron products. sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. The dosing for iron replacement treatment in pediatric patients with Peritoneal or Hemodialysis-Dependent - CKD or Non-Dialysis Dependent CKD have not been established. Iron metabolism needs to be balanced and bleeding, the major cause of iron deficiency (for instance in menstruation in females and chronic occult gastrointestinal bleeding) needs to be addressed. The cost of Venofer is $145 for a dose of 300 mg and Monoferric is $274 for a dose of 500mg. (See also Notes section. This cost includes the fee charged by the pharmacy. WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS Fatal and serious hypersensitivity reactions including anaphylaxis have occurred in patients receiving Feraheme. Anemia; 2015: 763576. Equations used: 1] Calculation of the Total Iron Deficit: Total iron deficit [mg] = body weight [kg] x (target Hb-actual Hb) [g/dl] x 2.4 + depot iron [mg]. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling [16.2].) This website also contains material copyrighted by 3rd parties. Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. By using this form you agree with the storage and handling of your data by this website. iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Dosing for patients who weigh 50 kg or more For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. 1 Dosing for patients who weigh less than 50 kg Due Date form Ultrasound Report. Applies only to oral form of both agents. Brand name: Venofer Drug class: Iron Preparations Chemical name: iron saccharate CAS number: 8047-67-4 Medically reviewed by Drugs.com on Oct 25, 2022. Contraindicated. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. Calculation of the Total Iron Deficit - Alternative equation Minor/Significance Unknown. Avoid or Use Alternate Drug. Schweiz Med Wochenschr. iron sucrose decreases levels of ibandronate by inhibition of GI absorption. In the text below the tool there is more information on how the iron deficit is calculated. For patients weighing less than 50 kg (110 lb): Give Injectafer in two doses separated by at least 7 days. Pediatric Patients: The most common adverse reactions (2%) are headache, respiratory tract viral infection, peritonitis, vomiting, pyrexia, dizziness, cough, nausea, arteriovenous fistula thrombosis, hypotension and hypertension. Avoid or Use Alternate Drug. After administration of iron dextran complex, evidence of a therapeutic response can be seen in a few days as an increase in the reticulocyte count. Anemias. Can't find what you need? Adding plans allows you to compare formulary status to other drugs in the same class. Avoid or Use Alternate Drug. 1970;100(7):301303. Minor/Significance Unknown. Fatal reactions have also occurred in situations where the test dose was tolerated. Venofer has not been studied in patients younger than 2 years old. Consult your pharmacist or local waste disposal company. Med J Aust. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Intravenous therapy is usually recommended in case of contraindications to oral iron, comorbidities that prevent absorption, chronic renal impairment or iron replacement needs to be rapid. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling (16.2).] Avoid or Use Alternate Drug. iron sucrose, captopril. David McAuley, Pharm.D. Parenteral Iron Replacement For Anemia Calculator - MDApp Indications: Feraheme is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have chronic kidney disease (CKD). Interaction only with oral iron administration. May increase risk of hypotension. Venofer (iron sucrose) 20 mg iron / ml, solution for injection or Applies only to oral form of both agents. pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. 2 *Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with CKD. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Here are the steps to follow for using this drug dosage calculator: First, enter the value of your Weight and choose the unit of measurement from the drop-down menu. Step 2: Calculation and administration of the maximum individual iron dose(s): . Max Dose. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Monitor Closely (1)sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. Interaction only with oral iron administration. Applies only to oral form of both agents. Minor/Significance Unknown. DailyMed - VENOFER- IRON SUCROSE injection, solution Use Caution/Monitor. Applies only to oral form of both agents. 1998 Feb;25(1):65-8. Monitor for signs and symptoms of hypotension following each administration of Venofer. Applies only to oral form of both agents. The dosing for iron replacement treatment in pediatric patients with HDD-CKD has not been established. Modify Therapy/Monitor Closely. FOR PATIENTS WEIGHING LESS THAN 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intravenous infusion 20 minutes . iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. Avoid or Use Alternate Drug. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Do not mix iron sucrose with other medications or TPN solution. Elemental iron product this is a choice between three iron supplement products: Iron dextran 50 mg/mL, Iron sucrose 20 mg/mL and Ferric gluconate 12.5 mg/mL. DOSAGE AND ADMINISTRATION: The recommended dose of Feraheme is an initial 510 mg dose followed by a second 510 mg dose 3 to 8 days later. J Lab Clin Med; 111(5):566-70. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session [see How Supplied/Storage and Handling (16.2).] The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 Hb in g/dL) x 2.145, Volume of product required in mL = Iron deficit in mg / C in mg/mL. J Lab Clin Med. Prior to and at regular intervals during parenteral iron therapy, evaluate serum iron, hemoglobin, and hematocrit. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. Nutrition. This site complies with the HONcode standard for trust- worthy health information: verify here. Philadelphia, PA: Lippincott Williams & Wilkins;2013;303-307. Accessed: 4/12/2011. cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Monitor Closely (1)didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Aranesp (darbepoetin alfa) | Dosing Considerations Applies only to oral form of both agents. Available for Android and iOS devices. iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Applies only to oral form of both agents. David McAuley, Pharm.D. This health tool computes the iron deficit based on patient parameters and the Ganzoni formula. Use Caution/Monitor. Corrected Calcium. Monitor Closely (1)aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14 [see How Supplied/Storage and Handling (16.2). Feraheme does not contain antimicrobial preservatives. Parenteral Iron Replacement For Iron Deficiency Anemia Calculator 1) Ganzoni AM. March 2, 2015 [IRON SUCROSE REQUIREMENT CALCULATION FOR SEVERE ANEMIA] DPMU Anantapuramu | National Health Mission 1 Formula for calculating the required dose of Iron sucrose 2.4 X Pre-pregnancy Weight in Kgs X Hb% deficit{11-actual Hb%} in mgs Plus Iron required to replenish the iron stores = 500mg Prepregnancy Weight = 45 kgs . Drug Dosing in Obesity Reference Table - ClinCalc.com Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Ferritin and transferrin are also recommended monitoring . https://www.uptodate.com/ (Requires subscription). Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. Separate by 2 hr. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] -Volume of parenteral iron product req'd (mL) = [Iron deficit (mg)] / C(mg/mL) Final calculations: -Hgb iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) -Volume of product required (mL) = [weight (kg)x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. PDF Injectafer (ferric carboxymaltose injection) - Food and Drug Administration Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Applies only to oral form of both agents. Iron Sucrose Dosage Guide + Max Dose, Adjustments - Drugs.com Intravenous iron sucrose: establishing a safe dose - PubMed Iron Deficiency In Pregnancy Calculator, Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator. You will have to pay for your IV iron. Ferrlecit may be diluted in 100 mL of 0.9% sodium chloride administered by intravenous infusion over 1 hour per dialysis session. Intravenous iron-dextran: therapeutic and experimental possibilities [in German] Schweiz Med Wochenschr. Venofer Injection Prescribing Information - Drugs.com Prescribing and dispensing information For iron sucrose A complex of ferric hydroxide with sucrose containing 2% (20 mg/mL) of iron. iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. Each mL contains 20 mg of elemental . SIDE EFFECTS: Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. Modify Therapy/Monitor Closely. iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Monitor Closely (1)iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Although the original formula requires the weight in kilograms, values input in lbs are transformed. Minor/Significance Unknown. Applies only to oral form of both agents. Venofer may cause clinically significant hypotension. Our dosage calculator can help you with this as well. Use Caution/Monitor.Minor (2)calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. This iron deficiency calculator determines the iron deficit based on patient weight, hemoglobin and iron stores to prepare for iron replacement. IMPORTANT SAFETY INFORMATION DOSAGE AND ADMINISTRATION Pediatric Patients (2 Years of Age and Older) Applies only to oral form of both agents. Observed Hb = the patients current hemoglobin in g/dl. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Applies only to oral form of both agents. Safety of highdose iron sucrose infusion in hospitalized patients with chronic kidney disease. Minor/Significance Unknown. Hollands J, Foote E, Rodriguez A. Ferrlecit has been administered at sequential dialysis sessions by infusion or by slow intravenous injection during the dialysis session itself. Deferasirox chelates iron. Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products (such as Venofer) which may cause fetal bradycardia, especially during the second and third trimester. We first individually analyzed 5 clinical studies, averaging the total iron deficit across all patients utilizing a . Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hgb conc. concentration of elemental iron (mg/ml) in the product being used: This calculator will help pinpoint potential causes of anemia based on an automated flowchart approach. * Adapted from the KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. Monitor Closely (1)trientine, iron sucrose. Minor/Significance Unknown. in the colostrum of 10 iron deficient breastfeeding women who were 2 to 3 days postpartum and received a single dose of 100 mg of intravenous iron . Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events. May increase risk of hypotension. Applies only to oral form of both agents. PDF PRODUCT MONOGRAPH - pdf.hres.ca The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. A: Generally acceptable. Since this is less than the threshold of total dose of 20 mg/kg, the deficit can be eliminated with a single infusion. Shirley, NY: American Regent, Inc.; 9/2020. calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. 2015: 763576. This site complies with the HONcode standard for trust- worthy health information: verify here. Sodium ferric gluconate (Ferrlecit) 62.5 mg . iron sucrose decreases levels of manganese by inhibition of GI absorption. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. The dose of Ferinject is based on calculation of ideal body weight and calculation of iron deficit using the Ganzoni formula. 4) Gozzard D. (2011) When is high-dose intravenous iron repletion needed? Monitor Closely (1)deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Each mL contains 20 mg of elemental iron. iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. In case a pediatric patient with a weight below 35 kg is assessed, iron stores are calculated as 15 mg iron for each kg. The normal ranges are: for males 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and for females 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Use Caution/Monitor. Where C= concentration of elemental iron (mg/ml) in the product being used: Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events, Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD), Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD), WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS, Iron Deficiency and Anemia- signs and therapeutic options. Applies only to oral form of both agents. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)- . Indications: Ferrlecit is an iron replacement product for treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Applies only to oral form of both agents. Andreas M. Ganzoni, MD, is a physician and researcher in the internal medicine department at the University of Zurich in Zurich, Switzerland. DICP. Uses for Iron Sucrose Administer Venofer early during the dialysis session (generally within the first hour). Maximum recommended single dose: 300 mg (See Prescriber's Orders). This information is not individual medical advice and does not substitute for the advice of your health care professional. Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. Minor/Significance Unknown. Total dose iron infusion: safety and efficacy in predialysis patients. Your doctor will do laboratory tests to monitor your response. Use Caution/Monitor. Situation Analysis Market Size MAT Sales Cr LC MAT Share % MAT Gr % Total Pharma Market 9388.69 100 13.5 Iron Sucrose 11.18 93.81 37.65 Brand Company Saline MAT . Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. The dosage of Venofer is expressed in mg of elemental iron. Initial symptoms may include hypotension, syncope, unresponsiveness, cardiac/cardiorespiratory arrest. Consult your doctor before breast-feeding. Clinical calculators for obstetrics and gynaecology - calculosaurus Venofer (iron sucrose) Uses, Dosage, Side Effects - Drugs.com Treatment of anemia due to iron deficiency. The prevention and treatment of iron deficiency is a major public health goal, especially in women, children, and individuals in low-income countries. Applies only to oral form of both agents. Use Caution/Monitor. Mode of Administration: Administer Venofer only intravenously by slow injection or by infusion. Medicinal forms Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. Use Caution/Monitor. VenAccess is a trademark of Vifor (International) Inc. Switzerland. Avoid or Use Alternate Drug. Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl over a period of 15 minutes. Adult Dosage and Administration: The recommended dosage of Ferrlecit for the repletion treatment of iron deficiency in hemodialysis patients is 10 mL of Ferrlecit (125 mg of elemental iron). 1 ,*. Applies only to oral form of both agents. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This may be helped by giving the medication more slowly or at a lower dose. Avoid or Use Alternate Drug. Recommended starting dose 1 Aranesp is dosed at 2.25 mcg/kg SC QW or 500 SC Q3W 1 (SC = subcutaneous) Before initiating 1: Evaluate iron status; administer supplemental iron therapy as needed Correct or eliminate other causes of anemia Initiate 1: Only when Hb < 10 g/dL The incidence of adverse events with the 400- and 500-mg doses administered as a 2-hour . Reactions have occurred following the first dose or subsequent doses of Venofer. Separate dosing of tetracyclines from these products. Patients measured hemoglobin can be input in g/dL or mmol/L. Applies only to oral form of both agents. You may report side effects to Health Canada at 1-866-234-2345. Applies only to oral form of both agents. Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course.
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